TABLE 4.

Inhibition of clinical isolates in PBMCs by MIs

Subtype	Virus name	Gag polymorphism(s)a	Mean EC50, μM
			GSK’254	GSK’795
B	93BR009	V218A/V370M/N372G	0.001	0.002
B	92BR003	A374P/T375N	0.002	0.004
B	93US143	I376M	0.002	NDb
B	93BR013	V370I/T375N	0.003	0.009
B	93BR008	V362I/N372T/A374T/T375N	0.050	0.123
B	92BR018	V218A/H219Q/V370A/ΔT371/T375A	0.077	0.145
B	93BR017	V218A/H219Q/A326S/V370A/ΔT371/S373T/T375A	0.001	0.010
C	98BR004	V218A/H219Q/A326S/ΔT371/A374T/T375N	0.001	0.001
C	MJ4	V218I/R286K/V370A/ΔT371/A374T/T375S	0.003	0.007
C	20706-3	ΔV370/A374S/ΔT375	0.004	0.004
C	93MW960	R286K/V370A/ΔlT371/ΔA374/T375N	0.009	1.575
C	10215-6	H219Q/R286K/ΔV370A/ΔT375	0.001	0.013
C	97ZA012	Not sequenced	0.003	0.004
A	93RW029	V218A/H219Q/T332S/P339T/A340G/G357S/V362I/V370A/T371Q/S373T/A374N	0.003	0.006
A	93RW034	Not sequenced	0.001	0.002
A	92UG037	Not sequenced	0.005	0.002
AE	93TH053	T332S/Q369F/V370A/ΔT371/N372Q/S373Q/T375N	0.005	0.018
AE	93TH023	T332S/V370A/ΔT371/N372Q/S373N/A374V/T375N	0.001	0.533
AE	CMU010	T332S/V370A/ΔT371/N372Q/S373H/T375N	0.003	0.035

^aDefined by changes at positions identified during resistance selection with GSK’795 (11) and changes from consensus between amino acids 369 and 376.

^bND, not determined.