TABLE 6.
Days to virus breakthrough under MI pressure with low and high MOIs
| MOI and virusa | GSK’254b |
GSK’795b |
||
|---|---|---|---|---|
| Expt 1, daysc | Expt 2, days | Expt 1, days | Expt 2, days | |
| Low MOI (0.005) | ||||
| Wild type | 14 (A366V) | >46 | >46 | 14 (A366A/V) |
| V370A | >46 | 11 (A364V) | 11 (V362I) | 18 |
| V362I | 46 (P289P/S) | >46 | 7 | 11 |
| V370M | >46 | 18 (A364V) | 7 | 11 |
| High MOI (0.05) | ||||
| Wild type | >46 | 18 (A364A/V, A366A/V) | 11 (A366A/V) | 14 (A366A/V, V362V/I) |
| V370A | >46 | >46 | 11 | 11 |
| V362I | 11 (A364V) | 11 (A364V) | 7 | 7 |
| V370M | 21 (A366A/V) | 11 (A366V) | 7 | 7 |
a
All viruses expressed Renilla luciferase reporter.
b
Experiments were run in duplicate. The drug was used at 80 nM.
c
Selected Gag region mutations reported in parentheses.