Supplementary Table 2.
Complete 13 steps of logistic regression using a backward Wald elimination of variables (response:Outcome)
| Regression coefficient (β) | SE | Wald | df | P | OR | 95% CI for OR (lower-upper) | |
|---|---|---|---|---|---|---|---|
| Step 1 | |||||||
| Age | −0.006 | 0.023 | 0.060 | 1 | 0.81 | 0.994 | 0.950-1.041 |
| Hospitalization period | −0.005 | 0.259 | 0.000 | 1 | 0.98 | 0.995 | 0.599-1.651 |
| Hydroxychloroquine (1) | 5.138 | 2.944 | 3.045 | 1 | 0.08 | 170.338 | 0.531-54631.996 |
| Ribavirin (1) | −1.854 | 4.555 | 0.166 | 1 | 0.68 | 0.157 | 0.000-1180.949 |
| Lopinavir/ritonavir (1) | 0.858 | 1.829 | 0.220 | 1 | 0.64 | 2.359 | 0.065-85.041 |
| Intravenous antibiotics (1) | −1.212 | 3.085 | 0.154 | 1 | 0.69 | 0.298 | 0.001-125.876 |
| Hydroxychloroquine (1) by age by severity (1) | 0.332 | 758.358 | 0.000 | 1 | 1.00 | 1.394 | 0.000 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.639 | 766.387 | 0.000 | 1 | 1.00 | 0.528 | 0.000 |
| Ribavirin (1) by age by severity (1) | 0.236 | 110.643 | 0.000 | 1 | 1.00 | 1.266 | 0.000-1.91E+94 |
| Diabetes (1) | −2.310 | 1.750 | 1.743 | 1 | 0.19 | 0.099 | 0.003-3.063 |
| Hypertension (1) | 2.513 | 2.062 | 1.485 | 1 | 0.22 | 12.338 | 0.217-702.334 |
| CODP/asthma (1) | 34.177 | 10895.71 | 0.000 | 1 | 1.00 | 6.96E+14 | 0.000 |
| Azithromycin (1) by hydroxychloroquine (1) | −0.087 | 11.366 | 0.000 | 1 | 0.99 | 0.917 | 0.000-4.34E+09 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.028 | 0.207 | 0.018 | 1 | 0.89 | 1.028 | 0.685-1.544 |
| Step 2 | |||||||
| Age | −0.006 | 0.023 | 0.056 | 1 | 0.81 | 0.994 | 0.950-1.041 |
| Hospitalization period | −0.005 | 0.259 | 0.000 | 1 | 0.98 | 0.995 | 0.598-1.653 |
| Hydroxychloroquine (1) | 5.153 | 2.953 | 3.046 | 1 | 0.08 | 173.034 | 0.530-56449.67 |
| Ribavirin (1) | −1.880 | 4.550 | 0.171 | 1 | 0.68 | 0.153 | 0.000-1138.985 |
| Lopinavir/ritonavir (1) | 0.823 | 1.828 | 0.202 | 1 | 0.65 | 2.276 | 0.063-81.890 |
| Intravenous antibiotics (1) | −1.183 | 3.091 | 0.146 | 1 | 0.70 | 0.306 | 0.001-131.156 |
| Hydroxychloroquine (1) by age by severity (1) | −0.307 | 110.404 | 0.000 | 1 | 1.00 | 0.735 | 0.000-6.96E+93 |
| Lopinavir/ritonavir (1) by age by severity (1) | 0.237 | 110.404 | 0.000 | 1 | 1.00 | 1.267 | 0.000-1.20E+94 |
| Diabetes (1) | −2.328 | 1.754 | 1.761 | 1 | 0.18 | 0.098 | 0.003-3.035 |
| Hypertension (1) | 2.514 | 2.068 | 1.478 | 1 | 0.22 | 12.349 | 0.215-710.559 |
| CODP/asthma (1) | 34.183 | 10874.87 | 0.000 | 1 | 1.00 | 7.01E+14 | 0.000 |
| Azithromycin (1) by hydroxychloroquine (1) | −0.172 | 11.412 | 0.000 | 1 | 0.99 | 0.842 | 0.000-4.36E+09 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.029 | 0.208 | 0.020 | 1 | 0.89 | 1.030 | 0.685-1.549 |
| Step 3 | |||||||
| Age | −0.005 | 0.023 | 0.048 | 1 | 0.83 | 0.995 | 0.950-1.042 |
| Hospitalization period | −0.042 | 0.255 | 0.027 | 1 | 0.87 | 0.959 | 0.582-1.582 |
| Hydroxychloroquine (1) | 4.688 | 2.644 | 3.142 | 1 | 0.08 | 108.594 | 0.609-19351.48 |
| Ribavirin (1) | 0.877 | 3.193 | 0.075 | 1 | 0.78 | 2.403 | 0.005-1254.142 |
| Lopinavir/ritonavir (1) | 0.775 | 1.764 | 0.193 | 1 | 0.66 | 2.171 | 0.068-68.939 |
| Intravenous antibiotics (1) | −0.656 | 2.807 | 0.055 | 1 | 0.82 | 0.519 | 0.002-127.192 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.117 | 0.057 | 4.245 | 1 | 0.04 | 0.889 | 0.795-0.994 |
| Diabetes (1) | −2.008 | 1.614 | 1.548 | 1 | 0.21 | 0.134 | 0.006-3.175 |
| Hypertension (1) | 2.341 | 2.026 | 1.336 | 1 | 0.25 | 10.395 | 0.196-550.987 |
| CODP/asthma (1) | 22.969 | 8943.755 | 0.000 | 1 | 1.00 | 9.45E+9 | 0.000 |
| Azithromycin (1) by hydroxychloroquine (1) | −0.318 | 10.665 | 0.001 | 1 | 0.98 | 0.727 | 0.000-8.71E+08 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.029 | 0.196 | 0.022 | 1 | 0.88 | 1.030 | 0.0701-1.512 |
| Step 4 | |||||||
| Age | −0.011 | 0.021 | 0.284 | 1 | 0.59 | 0.989 | 0.949-1.031 |
| Hospitalization period | 0.000 | 0.208 | 0.000 | 1 | 1.00 | 1.000 | 0.665-1.503 |
| Hydroxychloroquine (1) | 4.509 | 2.263 | 3.968 | 1 | 0.05 | 90.808 | 1.075-7669.183 |
| Ribavirin (1) | −1.436 | 1.434 | 1.003 | 1 | 0.32 | 0.238 | 0.014-3.950 |
| Lopinavir/ritonavir (1) | 1.732 | 1.835 | 0.891 | 1 | 0.35 | 5.651 | 0.155-206.167 |
| Intravenous antibiotics (1) | −0.348 | 2.299 | 0.023 | 1 | 0.88 | 0.706 | 0.008-63.937 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.088 | 0.030 | 8.904 | 1 | 0.003 | 0.915 | 0.864-0.970 |
| Diabetes (1) | −0.642 | 1.327 | 0.234 | 1 | 0.63 | 0.526 | 0.039-7.092 |
| Hypertension (1) | 0.945 | 1.449 | 0.425 | 1 | 0.51 | 2.573 | 0.150-43.992 |
| Azithromycin (1) by hydroxychloroquine (1) | −0.275 | 10.933 | 0.001 | 1 | 0.98 | 0.760 | 0.000-1.54E+09 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.024 | 0.199 | 0.015 | 1 | 0.90 | 1.025 | 0.693-1.514 |
| Step 5 | |||||||
| Age | −0.011 | 0.020 | 0.303 | 1 | 0.58 | 0.989 | 0.950-1.029 |
| Hydroxychloroquine (1) | 4.509 | 2.263 | 3.970 | 1 | 0.05 | 90.816 | 1.077-7661.056 |
| Ribavirin (1) | −1.436 | 1.399 | 1.054 | 1 | 0.31 | 0.238 | 0.015-3.689 |
| Lopinavir/ritonavir (1) | 1.731 | 1.779 | 0.948 | 1 | 0.33 | 5.648 | 0.173-184.408 |
| Intravenous antibiotics (1) | −0.349 | 2.141 | 0.027 | 1 | 0.87 | 0.705 | 0.011-46.833 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.088 | 0.030 | 8.942 | 1 | 0.003 | 0.915 | 0.864-0.970 |
| Diabetes (1) | −0.642 | 1.301 | 0.244 | 1 | 0.62 | 0.526 | 0.041-6.739 |
| Hypertension (1) | 0.946 | 1.353 | 0.489 | 1 | 0.49 | 2.574 | 0.182-36.487 |
| Azithromycin (1) by hydroxychloroquine (1) | −0.275 | 10.934 | 0.001 | 1 | 0.98 | 0.760 | 0.000-1.54E+09 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.024 | 0.199 | 0.015 | 1 | 0.90 | 1.025 | 0.694-1.514 |
| Step 6 | |||||||
| Age | −0.011 | 0.020 | 0.303 | 1 | 0.58 | 0.989 | 0.950-1.029 |
| Hydroxychloroquine (1) | 4.505 | 2.256 | 3.988 | 1 | 0.05 | 90.445 | 1.087-7523.718 |
| Ribavirin (1) | −1.433 | 1.393 | 1.059 | 1 | 0.30 | 0.239 | 0.016-3.657 |
| Lopinavir/ritonavir (1) | 1.730 | 1.777 | 0.948 | 1 | 0.33 | 5.640 | 0.173-183.460 |
| Intravenous antibiotics (1) | −0.353 | 2.135 | 0.027 | 1 | 0.87 | 0.703 | 0.011-46.125 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.088 | 0.029 | 9.016 | 1 | 0.003 | 0.915 | 0.864-0.970 |
| Diabetes (1) | −0.641 | 1.298 | 0.244 | 1 | 0.62 | 0.527 | 0.041-6.704 |
| Hypertension (1) | 0.948 | 1.349 | 0.494 | 1 | 0.48 | 2.580 | 0.183-36.317 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.019 | 0.031 | 0.386 | 1 | 0.53 | 1.020 | 0.959-1.084 |
| Step 7 | |||||||
| Age | −0.011 | 0.020 | 0.301 | 1 | 0.58 | 0.989 | 0.951-1.029 |
| Hydroxychloroquine (1) | 4.228 | 1.465 | 8.334 | 1 | 0.004 | 68.595 | 3.887-1210.632 |
| Ribavirin (1) | −1.387 | 1.352 | 1.052 | 1 | 0.31 | 0.250 | 0.018-3.538 |
| Lopinavir/ritonavir (1) | 1.637 | 1.669 | 0.963 | 1 | 0.33 | 5.142 | 0.195-135.378 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.088 | 0.029 | 9.023 | 1 | 0.003 | 0.915 | 0.864-0.970 |
| Diabetes (1) | −0.595 | 1.267 | 0.221 | 1 | 0.64 | 0.551 | 0.046-6.605 |
| Hypertension (1) | 0.876 | 1.278 | 0.470 | 1 | 0.49 | 2.401 | 0.196-29.374 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.019 | 0.031 | 0.374 | 1 | 0.54 | 1.019 | 0.959-1.084 |
| Step 8 | |||||||
| Age | −0.014 | 0.019 | 0.503 | 1 | 0.48 | 0.986 | 0.950-1.024 |
| Hydroxychloroquine (1) | 4.283 | 1.454 | 8.683 | 1 | 0.003 | 72.486 | 4.197-1251.864 |
| Ribavirin (1) | −1.316 | 1.354 | 0.943 | 1 | 0.33 | 0.268 | 0.019-3.816 |
| Lopinavir/ritonavir (1) | 1.804 | 1.646 | 1.201 | 1 | 0.27 | 6.074 | 0.241-152.889 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.093 | 0.030 | 9.905 | 1 | 0.002 | 0.911 | 0.860-0.966 |
| Hypertension (1) | 0.740 | 1.240 | 0.357 | 1 | 0.55 | 2.096 | 0.185-23.798 |
| Age by azithromycin (1) by hydroxychloroquine (1) | 0.014 | 0.028 | 0.246 | 1 | 0.62 | 1.014 | 0.960-1.072 |
| Step 9 | |||||||
| Age | −0.015 | 0.019 | 0.572 | 1 | 0.45 | 0.985 | 0.949-1.024 |
| Hydroxychloroquine (1) | 4.421 | 1.440 | 9.427 | 1 | 0.002 | 83.165 | 4.947-1398.057 |
| Ribavirin (1) | −1.214 | 1.336 | 0.826 | 1 | 0.36 | 0.297 | 0.022-4.071 |
| Lopinavir/ritonavir (1) | 1.842 | 1.656 | 1.237 | 1 | 0.27 | 6.307 | 0.246-161.963 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.096 | 0.029 | 10.66 | 1 | 0.001 | 0.909 | 0.858-0.962 |
| Hypertension (1) | 0.970 | 1.170 | 0.687 | 1 | 0.41 | 2.638 | 0.266-26.141 |
| Step 10 | |||||||
| Hydroxychloroquine (1) | 3.768 | 1.121 | 11.30 | 1 | 0.001 | 43.299 | 4.814-389.415 |
| Ribavirin (1) | −0.868 | 1.235 | 0.494 | 1 | 0.48 | 0.420 | 0.037-4.725 |
| Lopinavir/ritonavir (1) | 1.029 | 1.211 | 0.722 | 1 | 0.40 | 2.798 | 0.261-30.063 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.089 | 0.026 | 11.86 | 1 | 0.001 | 0.915 | 0.870-0.962 |
| Hypertension (1) | 0.780 | 1.141 | 0.467 | 1 | 0.49 | 2.181 | 0.233-20.415 |
| Step 11 | |||||||
| Hydroxychloroquine (1) | 3.812 | 1.086 | 12.32 | 1 | <0.001 | 45.248 | 5.388-379.982 |
| Ribavirin (1) | −0.789 | 1.242 | 0.404 | 1 | 0.53 | 0.454 | 0.040-5.183 |
| Lopinavir/ritonavir (1) | 1.159 | 1.173 | 0.977 | 1 | 0.32 | 3.186 | 0.320-31.720 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.085 | 0.025 | 11.63 | 1 | <0.001 | 0.918 | 0.874-0.964 |
| Step 12 | |||||||
| Hydroxychloroquine (1) | 3.703 | 1.026 | 13.023 | 1 | <0.001 | 40.552 | 5.428-302.931 |
| Lopinavir/ritonavir (1) | 1.063 | 1.126 | 0.891 | 1 | 0.35 | 2.895 | 0.319-26.316 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.092 | 0.024 | 14.950 | 1 | <0.001 | 0.912 | 0.871-0.956 |
| Step 13 | |||||||
| Hydroxychloroquine (1) | 4.125 | 0.983 | 17.609 | 1 | <0.001 | 61.859 | 9.009-424.722 |
| Lopinavir/ritonavir (1) by age by severity (1) | −0.081 | 0.020 | 17.300 | 1 | <0.001 | 0.922 | 0.887-0.958 |
OR=Odds ratio; CI=Confidence interval; SE=Standard deviation