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. 2022 Jan 14;15:311–324. doi: 10.2147/JIR.S342399

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© 2022 Jensen et al.

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Dietary fish oil increases NK cell expression of CD107a and the proportion of NK cells that express CD107a but decreases the proportion of NK cells expressing CD62L. Mice were fed control (Ctr, grey line with grey circles) or fish oil (Fo, black line with black squares) diets for 5 weeks. They were immunized twice with mBSA with a 2-week interval and subsequently challenged intraperitoneally. Mice were sacrificed at 6 h following challenge and peritoneal cells collected, counted with a Countess automated cell counter, stained with monoclonal antibodies against CD3, NK1.1, CD49b (DX5), CD107a, and CD62L, and evaluated by flow cytometry. Representative dot plots of CD107a (A) and CD62L (B) expression on NK cells in mice receiving Fo and Ctr diets 6 h after inflammation induction. Expression levels (MFI) and percentages of CD107a⁺ (C) and CD62L⁺ (D) NK cells 6 h following induction of inflammation. *p < 0.05, **p < 0.01; n = 13–14. Results are shown as mean ± standard error of the mean from data collected from at least four independent experiments.