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. 2022 Jan 14;15:311–324. doi: 10.2147/JIR.S342399

Figure 7.

Figure 7

Dietary fish oil dampens pro-inflammatory lipid mediator concentrations, increases anti-inflammatory HEPEs concentrations and increases the ratio of HEPEs to HETEs. Mice were fed control (Ctr, grey line with grey circles) or fish oil (Fo, black line with black squares) diets for 5 weeks. They were immunized twice with mBSA with a 2-week interval and subsequently challenged intraperitoneally. Mice were sacrificed at 0, 3, 6, and 12 h following challenge and peritoneal lavage collected. Peritoneal concentrations of PGD2 (A), PGE2 (B), PGF2α, (C), TXB2 (D), 5-HEPE (E), 12-HEPE (F), 15-HEPE (G), 18-HEPE (H) and 5-HETE, 12-HETE, and 15-HETE were determined by tandem LC-MS/MS and 5-HEPE/5-HETE (I), 12-HEPE/12-HETE (J), and 15-HEPE/15-HETE (K) calculated for each mouse at the indicated timepoints. (*)p < 0.1, *p < 0.05, **p < 0.01, ***p < 0.001; n = 6 for all time-points. Results are shown as mean ± standard error of the mean from data collected from at least two independent experiments.