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. 2022 Jan 4;15:720286. doi: 10.3389/fnins.2021.720286

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Copyright © 2022 Chen, Zheng, Yan, Zhu, Zeng, Zheng, Li, Yao, Xia, Su and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Maternal separation induces different behaviors in adolescent and adult rats. (A) The experimental timeline of MS, behavioral tests. (B) Upper: representative traces of the movement of adolescent and adult rats in the open field experiment. Lower: the total distance in the open field experiment of adolescent and adult rats, respectively. (C) MS decreased the time spent in the center area compared to control rats in adolescent, while there was no difference between MS and control in adulthood. (D) Upper: representative traces of the movement of adolescent and adult rats in the Elevated-Plus-Maze Test. Lower: compared to Control groups, MS induces a decrease of the time in open arms for adolescent rats, but no change in rats with MS compared to control rats in adult. (E) MS increased the latency of time to feed compared to control rats in adolescent, while there was no difference between MS and control in adulthood. (F) Reduced sucrose preference rate by rats with MS in SPT test compared to control group rats whether in adolescence or adulthood. (G) Immobility time in rats with MS compared to control rats was no change of adolescent rats in the forced swimming test, but induce an aggravation in immobility time in rats with MS compared to control rats in adult. (Adolescent: n = 15 rats each group; Adult: n = 12 rats each group) *p < 0.05, **p < 0.01. Data are the means ± SEM.