Skip to main content
. 2022 Jan 4;15:720286. doi: 10.3389/fnins.2021.720286

FIGURE 2.

FIGURE 2

Maternal separation induces an increase in neuronal excitability in L5 pyramidal cells in adolescence. (A) The experimental timeline of MS, whole-cell recording (AP analysis). (B) Representative trace of AP from the L5 pyramidal cell in PrL with current clamp under the condition of injecting incremental step currents of 0, +50, +150, +250, and +350 pA in control and MS at adolescent. Scale bars: 40 mV, 200 ms. (C) The frequency of action potential firing of pyramidal neurons in control and MS at adolescent. (D) The resting membrane potential of action potential of pyramidal neurons in control and MS at adolescent. (E) The input resistance of action potential of pyramidal neurons in control and MS at adolescent. (F) The threshold of action potential of pyramidal neurons in control and MS at adolescent. (G) The membrane time constant of action potential of pyramidal neurons in control and MS at adolescent. (H) The duration of the action potential measured at half-amplitude of pyramidal neurons in control and MS at adolescent. (I) The amplitude of action potential of pyramidal neurons in control and MS at adolescent. *p < 0.05, **p < 0.01. Data are the means ± SEM (n = 14 cells from 3 to 4 rats each group).