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. 2022 Jan 4;15:720286. doi: 10.3389/fnins.2021.720286

FIGURE 3.

FIGURE 3

Maternal separation induces a decrease in neuronal excitability in L5 pyramidal cells in adulthood. (A) The experimental timeline of MS, whole-cell recording (AP analysis). (B) Representative trace of AP from the L5 pyramidal cell in PrL with current clamp under the condition of injecting incremental step currents of 0, +50, +150, +250, and +350 pA in control and MS at adult. Scale bars: 40 mV, 200 ms. (C) The frequency of AP firing of pyramidal neurons in control and MS at adult. (D) The threshold of action potential of pyramidal neurons in control and MS at adult. (E) The resting membrane potential of action potential of pyramidal neurons in control and MS at adult. (F) The input resistance of action potential of pyramidal neurons in control and MS at adult. (G) The membrane time constant of action potential of pyramidal neurons in control and MS at adult. (H) The duration of the action potential measured at half-amplitude of pyramidal neurons in control and MS at adult. (I) The amplitude of action potential of pyramidal neurons in control and MS at adult. *p < 0.05, **p < 0.01. Data are the means ± SEM (n = 15 cells from 3 to 4 rats each group).