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. 2022 Jan 4;15:720286. doi: 10.3389/fnins.2021.720286

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Copyright © 2022 Chen, Zheng, Yan, Zhu, Zeng, Zheng, Li, Yao, Xia, Su and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased E/I balance of L5 pyramidal cells in adult MS rats. (A) The experimental timeline of MS, whole-cell recording (E/I analysis). (B) Representative sEPSC (upper) and sIPSC (lower) current traces at a holding potentiation of –60 and +10 mV, respectively. Scale bars: 20 pA, 400 ms. (C–E) Changes in the amplitude, frequency, and quantification of sEPSC current recorded by isolated patch clamp in adult rats. (F–H) Changes in the amplitude, frequency, and quantification of sIPSC current recorded by isolated patch clamp in adult rats. (I) sEPSC/sIPSC charge transfer ratios. *p < 0.05, **P < 0.01. Data are the means ± SEM (n = 14–15 cells from 3 to 4 rats each group).