Skip to main content
. 2022 Jan 18;17(1):e0262785. doi: 10.1371/journal.pone.0262785

Fig 5. Detection and quantification of the TGF-β and MMP-9 in fatal cases of DENV.

Fig 5

(A) Detection of TGF-β in pancreatic islet cells and differentiated macrophages in both fatal cases. Control tissue showed a constitutive expression of this cytokine. (B) Quantitative analysis of TGF-β expression exhibited a significantly increase in infected tissues compared to control tissues. (C) MMP-9 expressed by islet cells and macrophages in DENV fatal cases. The detection of this metalloproteinase was not observed in control tissues. (D) The quantitative analysis of MMP-9 expression showed increased levels in both cases. Macrophages (MØ); Pancreatic Islets (IL). Data are represented as mean ± SDM. (a and b) indicate differences that are statistically significant between individual specimens (p < 0.05).