Comparison 1. Longer interval (5‐15 days) (intervention) versus shorter interval (2‐5 days) (control).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Catheter related blood stream infection	1	995	Risk Ratio (M‐H, Fixed, 95% CI)	1.42 [0.40, 4.98]
2 Suspected catheter related blood stream infection	2	151	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.23, 2.10]
3 All‐cause mortality	3	896	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.90, 1.25]
4 Catheter‐site infection	2	371	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.71, 1.63]
5 Skin damage	2		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
6 Pain	2	193	Risk Ratio (M‐H, Random, 95% CI)	0.80 [0.46, 1.38]