Little or no historical data may be available
|
Bioterrorism, newly emerging diseases |
Simulated data is sensitive to modelling
assumptions
|
Patients’ health-seeking behaviour is difficult to
predict |
Event may not be routinely monitored by non-syndromic
systems
|
Seasonal hay fever |
Exposure may be clearly defined but impact on public
health is still uncertain
|
Heat waves |
Laboratory ‘gold-standard’ for independent
verification may not exist
|
Newly emerging pathogen |
Precise start and end date of exposure might be
uncertain
|
Seasonal influenza |
Events causing similar symptoms may occur at the same
time
|
Air pollution and seasonal respiratory illness |
Control period without events may be unavailable
|
Syndromic baseline data is rarely zero |