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. 2022 Jan 11;2022:1839341. doi: 10.1155/2022/1839341

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Copyright © 2022 Jing Luo et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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OLV induces inflammatory activation and lung permeability changes. (a, b) H&E staining detected the pathology of lung tissues in OLV and control rats. (c) The lung W/D ratio between OLV and control rats was calculated according to the formula [weight (wet) − weight (dry)]/weight (dry). (d) The PMN/WBC ratio of BALF in OLV and control rats was calculated. (e–k) ELISA performed to examine the levels of inflammation mediators (GM-CSF, IL-1β, IL-8, KC, MCP-1, MIP-2, and TNF-α) between the OLV group and control rats. (l–o) Western blot detected the protein levels of Bcl-2, Bax, caspase 3, MLCK, VE-cadherin, occludin, and ZO-1 in OLV and control rats. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.