Table 1.

Non-coding RNAs in the pathogenesis of GO.

Noncoding-RNAs	Samples/cells	Expression change	Function	Effects in GO	References
miR-146a	Plasma	Downregulation	Promote the differentiation of Th17 cell	Pro-inflammatory	(62)
	CD4+ T	Downregulation	Increase Th1 response	Pro-inflammatory	(63, 64)
	Orbital tissue	Upregulation	Increase the IL-6 level	Exacerbate GO	(69)
	Orbital tissue	Upregulation	Decreases FN, collagen Iα, and α -SMA	Inhibit fibrosis process	(72, 73)
miR-183 and miR-96	CD4+ T	Upregulation	Contribute to the activation of CD4+ T cells	Pro-inflammatory	(66)
miR-21-5P	Orbital tissue	Upregulation	Promote collagen Iα and total collagen production	Promote fibrogenesis	(76)
miR-146a and miR-155	Orbital tissue	Upregulation	Reducing the expression of PTEN and ZNRF3	Promote proliferation	(70)
m iR-27a and miR-27b	Orbital tissue	Downregulation	Cause the adipogenic differentiation of OFs	Promote adipogenesis	(79)
m iR-130a	Orbital tissue	Upregulation	Enhance lipid accumulation	Fatty tissue accumulation	(78)
circRNA_14940	Orbital tissue	Upregulation	Regulate the Wnt signaling pathway, ECM receptor interaction and PIK3-AKT signaling pathway	Participate in the pathogenesis of GO	(80)