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. 2022 Jan 5;15:803057. doi: 10.3389/fncel.2021.803057

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Copyright © 2022 Barber, Ali and Kucenas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mediators of OPC tiling. (A) Diagram of a developing OPC in the spinal cord with chemotactic signaling molecules that guide either chemorepellent or chemoattractant migration. Chemoattractants include: Fibroblast growth factor (Fgf) signaling through its receptor Fibroblast growth factor receptor (Fgfr), Platelet-derived growth factor (Pdgf) signaling through its receptor Platelet-derived growth factor receptor alpha (Pdgfrα), Hepatocyte growth factor (Hgf) signaling through its receptor Mesenchymal-epithelial transition (Met), C-x-c motif chemokine ligand 12 (Cxcl12) signaling through its receptor C-x-c chemokine receptor 4 (Cxcr4), and 2-Arachidonoylgylcerol (2-AG) signaling through its receptors Cannabinoid receptor type 1 and type 2 (CB1/2). Chemorepellents include: C-x-c motif chemokine ligand 1 (Cxcl1) signaling through its receptor C-x-c motif chemokine receptor 2 (Cxcr2), Netrin-1 (Ntn1) signaling through its receptor Deleted in colorectal carcinoma (Dcc), and Chondroitin Sulfate Proteoglycans (CSPGs) signaling through their cognate receptors. A cocktail of various CSPGs was used in this study, making it unclear exactly which CSPGs mediate this process. (B) Venn-Diagram demonstrating mediators that contribute to multiple tiling processes. GDE3, Glycerophosphodiester phosphodiesterase 3; ASCL1, Achaete-Scute Family BHLH Transcription Factor 1; Lingo1, Leucine-Rich Repeat and Immunoglobulin-like Domain Containing Nogo Receptor-Interacting Protein 1; PCDH15, Protocadherin Related 15.