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. 2022 Jan 7;26(1):117–127. doi: 10.1007/s40291-021-00573-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 5 — Heat map analysis. The expression variation of off-target genes of gap-GR14 in the cells treated with gap-GR18-1, gap-GR18-2, and gap-GR18-3. The off-target genes of gap-GR14 are classified into the d = 0 group [glucocorticoid receptor (GR) and five genes] and d = 1 (168 genes) in the left panel, the d = 2 group (1539 genes) in the right panel. Up-regulated genes are presented in shades of green and down-regulated genes in shades of red