Table 2.
Plasma parameters of healthy and nephrotic Habp2+/+ and Habp2−/− mice before and on day 10 of experimental nephrotic syndrome.
| Healthy | Nephrotic | |||
|---|---|---|---|---|
| Habp2+/+ | Habp2−/− | Habp2+/+ | Habp2−/− | |
| pH | 7.24 ± 0.2 | 7.30 ± 0.01 | 7.29 ± 0.02 | 7.32 ± 0.02 |
| std HCO3−, mM | 22 ± 0.4 | 21 ± 1 | 24 ± 1 | 25 ± 2 |
| Na+, mM | 147 ± 0.4 | 147 ± 1 | 139 ± 2# | 143 ± 2 |
| K+, mM | 4.4 ± 0.1 | 4.2. ± 0.1 | 5.8 ± 0.2# | 5.7 ± 0.4# |
| Ca++, mM | 1.09 ± 0.01 | 1.06 ± 0.02 | 1.11 ± 0.02 | 1.09 ± 0.05 |
| Hct, % | 44.3 ± 0.7 | 43.7 ± 0.8 | 37.2 ± 2.5# | 43.7 ± 1.7 |
| cHbc, g dL−1 | 14.6 ± 0.2 | 14.4 ± 0.2 | 12.3 ± 0.8 | 14.5 ± 0.6 |
| urea, mg dL−1 | 51 ± 7 | 39 ± 3 | 58 ± 15 | 78 ± 28 |
| albumin, g L−1 | 34 ± 2 | 35 ± 2 | 12 ± 1# | 13 ± 2# |
Arithmetic means ± SEM. Parameters from venous blood gas analysis were determined in n = 7–9 mice per group. Plasma urea and albumin concentration was determined in n = 4 mice per group. #Significant difference between healthy and nephrotic state; Abbreviations: std standard, Hct hematocrit, cHbc calculated hemoglobin concentration