Table 1.
Characteristics of included studies
| Study number | Region | No. of patients tested for EGFR | Mean age, years | Male, % | Adenocarcinoma, % | All EGFR mutation, % | EGFR exon 19 deletions, %a | Exon 21 L858R substitutions, %a | Other submutations, %a | References |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Europe | 282 | 64.0 | 45.7 | 100.0 | b | 45.0 | 28.0 | 27.0 | [25] |
| 2 | Europe | 2052 | N/A | N/A | N/A | 10.6 | 41.3 | 32.1 | 26.6 | [26] |
| 3 | Europe | 181 | 71.4 | 38.1 | 89.0 | b | 57.1 | 22.6 | 20.3 | [27] |
| 4 | Europe | 360c | 62.0 | 47.5 | 97.5 | 15.3 | 42.5 | 40.0 | 17.5 | [28] |
| 5 | Europe | 778 | N/A | 54.1 | 79.7 | 9.1 | 54.9 | 29.6 | 15.5 | [29] |
| 6 | Europe | 462 | 66.0 | 49.4 | 68.2 | 12.3 | 57.9 | 22.8 | 19.3 | [30] |
| 7 | Europe | 4196 | 66.0 | 62.1 | 69.4 | 10.3 | 48.3 | 35.3 | 16.5 | [31] |
| 8 | Europe | 1201 | N/A | 61.2 | 84.1 | 9.8 | 61.0 | 22.9 | 16.1 | [32] |
| 9 | Europe | 753 | 65.0 | 62.0 | 80.0 | 16.1 | 47.3 | 24.8 | 27.9 | [33] |
| 10 | Europe | 3269 | 68.4 | 52.6 | 46.6 | 9.3 | 38.9 | 30.4 | 30.4 | [34] |
| 11 | Europe | 1427 | 61.0 | 75.1 | 40.4 | 8.9 | 52.0 | 42.5 | 5.5 | [35] |
| 12 | Europe | 1785 | 64.0 | 60.7 | 78.0 | 13.8 | 43.3 | 28.3 | 36.4 | [36] |
| 13 | Asia | 484 | N/A | 57.6 | 88.4 | 37.6 | 56.6 | 33.5 | 9.9 | [37] |
| 14 | Asia | 177 | 60.0 | 48.0 | 100.0 | b | 53.1 | 40.1 | 13.6 | [38] |
| 15 | Asia | 310 | 57.0 | 52.3 | 100.0 | 42.9 | 46.6 | 45.1 | 8.3 | [39] |
| 16 | Asia | 627 | 58.0 | 61.1 | 87.7 | 38.8 | 53.5 | 40.3 | 6.2 | [40] |
| 17 | Asia | 441 | 60.3 | 62.6 | 70.4 | 37.6 | 56.6 | 28.9 | 14.5 | [41] |
| 18 | Asia | 1230d | N/A | N/A | 100.0 | 38.5 | 43.6 | 50.5 | 5.9 | [42] |
| 19 | Asia | 74 | 59.0 | 25.0 | 97.0 | b | 50.0 | 46.0 | 4.0 | [43] |
| 20 | Asia | 437 | 57.0 | 36.9 | N/A | 59.7 | 53.6 | 42.5 | 8.0 | [44] |
| 21 | Asia | 134 | 57.0 | 57.7 | 75.7 | 50.7 | 60.3 | 29.4 | 10.3 | [45] |
| 22 | Asia | 159 | 63.0 | 39.6 | 100.0 | b | 54.1 | 42.1 | 3.8 | [46] |
| 23 | Asia | 1672 | N/A | 57.6 | N/A | 27.8 | 58.9 | 39.8 | 1.3 | [47] |
| 24 | Asia | 69 | 61.0 | 60.9 | 100.0 | b | 52.2 | 43.5 | 4.3 | [48] |
| 25 | Asia | 741 | 57.4 | 53.0 | 100.0 | 50.2 | 48.9 | 45.4 | 5.6 | [49] |
| 26 | Asia | 145 | 64.0 | 57.0 | 86.0 | 44.1 | 46.9 | 37.5 | 15.6 | [50] |
| 27 | Asia | 1450 | 60.0 | 56.6 | 94.9 | 51.4 | 43.0 | 40.6 | 16.4 | [51] |
| 28 | Asia | 879 | 63.0 | 50.8 | 78.6 | b | 48.0 | 48.7 | 3.3 | [52] |
| 29 | Asia | 183 | N/A | 43.5 | 100.0 | 65.0 | 51.3 | 37.0 | 11.8 | [53] |
| 30 | Asia | 178 | 68.0 | 49.4 | 100.0 | 53.4 | 35.8 | 51.6 | 12.6 | [54] |
| 31 | Asia | 228 | 59.3 | 43.4 | 60.5 | b | 53.1 | 38.2 | 8.8 | [55] |
| 32 | Asia | 169 | 53.2 | 52.1 | 100.0 | 49.1 | 50.6 | 41.0 | 8.4 | [56] |
| 33 | Asia | 552 | N/A | N/A | N/A | 64.5 | 40.2 | 42.7 | 17.1 | [57] |
| 34 | Asia | 148 | 65.2 | 51.0 | 86.8 | b | 49.5 | 41.8 | 8.8 | [58] |
| 35 | Asia | 598e | 62.0 | 56.5 | 81.3 | 49.0 | 57.1 | 28.6 | 14.3 | [59] |
| 36 | Asia | 169 | 56.0 | 68.6 | 100.0 | 37.9 | 57.8 | 35.9 | 6.3 | [60] |
| 37 | Asia | 496 | 62.0 | 45.8 | 100.0 | 58.7 | 40.2 | 38.8 | 21.0 | [61] |
| 38 | Asia | 134 | 56.0 | 73.1 | 80.6 | b | 60.3 | 29.4 | 10.3 | [62] |
| 39 | Asia | 109 | N/A | 46.8 | 100.0 | 56.9 | 50.0 | 37.1 | 12.9 | [63] |
| 40 | Asia | 1632 | N/A | N/A | 100.0 | 51.5 | 42.1 | 42.4 | 15.5 | [64] |
| 41 | Asia | 145 | 57.5 | 37.0 | 100.0 | b | 44.1 | 48.3 | 7.6 | [65] |
| 42 | Asia | 16,840 | N/A | N/A | 100.0 | 35.0 | 44.6 | 44.7 | 10.6 | [66] |
| 43 | Asia | 266 | 57.0 | 53.4 | 91.0 | 45.5 | 52.9 | 41.3 | 5.8 | [67] |
| 44 | Asia | 69 | 56.0 | 55.1 | 88.4 | b | 52.9 | 35.3 | 11.8 | [68] |
| 45 | Asia | 575 | 59.6 | 62.7 | 70.5 | 36.3 | 56.5 | 29.7 | 13.9 | [69] |
| 46 | Asia | 217 | 59.0 | 44.7 | 80.2 | 63.1 | 50.4 | 40.9 | 8.8 | [70] |
| 47 | Asia | 949 | N/A | 58.7 | 100.0 | 51.4 | 44.5 | 45.9 | 9.6 | [71] |
| 48 | Asia | 259 | 68.0 | 64.5 | 70.0 | 28.2 | 56.2 | 31.5 | 12.3 | [72] |
| 49 | Asia | 812 | 59.0 | 51.0 | 100.0 | 39.5 | 59.5 | 37.7 | 6.5 | [73] |
| 50 | Asia | 246 | 68.0 | 58.0 | 100.0 | 39.8 | 42.9 | 53.1 | 5.1 | [74] |
| 51 | Asia | 207 | 60.8 | 37.7 | 97.1 | b | 52.7 | 42.0 | 5.3 | [75] |
| 52 | Asia | 1195 | N/A | 56.4 | 90.8 | 46.4 | 42.3 | 40.0 | 17.7 | [76] |
| 53 | Asia | 229 | 61.0 | 55.5 | 48.9 | 52.4 | 50.1 | 41.7 | 8.3 | [77] |
| 54 | Asia | 220 | 59.0 | 55.9 | 80.0 | 51.8 | 56.1 | 30.7 | 20.2 | [78] |
| 55 | Asia | 206 | 55.8 | 47.6 | 100.0 | 51.5 | 44.3 | 40.6 | 15.1 | [79] |
| 56 | Asia | 90 | 66.7 | 35.8 | 91.5 | 61.1 | 36.4 | 41.8 | 21.8 | [80] |
| 57 | Asia | 265 | N/A | 45.3 | 100.0 | 55.8 | 45.9 | 47.3 | 6.8 | [81] |
| 58 | Asia | 170 | 57.1 | 54.7 | 85.3 | 58.2 | 40.4 | 47.5 | 12.1 | [82] |
| 59 | Asia | 352 | 59.0 | 49.1 | 77.6 | 64.8 | 53.5 | 44.7 | 1.8 | [83] |
| 60 | Asia | 140 | 57.5 | 64.3 | 59.3 | 72.9 | 32.4 | 35.3 | 32.4 | [84] |
| 61 | Asia | 100 | 53.0 | 57.0 | 90.0 | 51.0 | 51.0 | 35.3 | 13.7 | [85] |
| 62 | Asia | 246 | 67.0 | 63.0 | 100.0 | 41.0 | 45.0 | 48.0 | 7.0 | [86] |
| 63 | Asia | 171 | 61.0 | 53.2 | N/A | b | 54.1 | 44.4 | 1.5 | [87] |
| 64 | N. America | 860 | N/A | 41.2 | 100.0 | 27.0 | 48.3 | 30.2 | 21.6 | [88] |
| 65 | N. America | 289 | 62.4 | 40.0 | 100.0 | 18.7 | 33.3 | 27.8 | 38.9 | [89] |
| 66 | N. America | 838 | 61.0 | 40.6 | 100.0 | 22.7 | 44.7 | 26.3 | 28.9 | [90] |
| 67 | N. America | 336 | 61.0 | 41.0 | 87.0 | 16.7 | 41.1 | 35.7 | 30.4 | [91] |
| 68 | N. America | 1009 | 66.0 | 41.1 | 89.1 | 19.0 | 41.1 | 31.3 | 27.6 | [92] |
| 69 | Central America | 165 | N/A | 40.3 | 100.0 | 41.8 | 46.3 | 33.3 | 20.4 | [93] |
| 70 | Oceania | 500 | 70.0 | 49.8 | 61.4 | 21.8 | 40.4 | 33.0 | 26.6 | [94] |
| 71 | S. America | 72 | 62.0 | 26.4 | 100.0 | b | 66.7 | 27.8 | 5.6 | [95] |
| 72 | Global | 129 | 61.0 | 42.0 | 100.0 | b | 40.0 | 42.0 | 18.0 | [96] |
| 73 | Global | 121 | 61.5 | 50.4 | 71.1 | b | 56.2 | 27.3 | 16.5 | [97] |
| 74 | Global | 1048f | 61.2 | 59.1 | 93.0 | 10.4 | 50.5 | 35.8 | 13.8 | [98] |
EGFR epidermal growth factor receptor, N north, N/A not available, S south
aRelative to the overall EGFR mutation population
bStudy was excluded from the All EGFR mutation analysis
cn = 40 for submutation analyses
dn = 872 for submutation analyses
en = 99 for submutation analyses
fn = 109 for submutation analyses