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. 2022 Jan 5;9:800833. doi: 10.3389/fcell.2021.800833

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Copyright © 2022 Huang, Wang, Li, Ye, Chen, Wang and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of five hub ferroptosis-related genes (FRGs). (A) Protein–protein interaction (PPI) network of 59 differentially expressed FRGs (DE-FRGs). Red indicates the driver of ferroptosis, light blue indicates the marker of ferroptosis, and green indicates the suppressor of ferroptosis. (B) Two clusters of the PPI network. (C) Hub genes calculated using the maximum neighborhood component (MNC), degree, and edge percolated component (EPC) algorithms.