Table 3.

EV cargos related to OC metastasis.

Function	EV cargo	Original cell	Recipient cell	Signaling pathways/Mechanism	Reference
Angiogenesis	MiR-141-3p	SKOV3	Endothelial cell	Activate the JAK-STAT3 signaling pathway and upregulate the expression of VEGFR-2	[79]
	MiR-205	HO-8910, SKOV3	Endothelial cell	Silence PTEN activates the AKT signaling pathway and upregulating the expression of VEGFA	[80, 81]
	LncRNA ENST00000444164, LncRNA ENST0000043768	SKOV3	HUVECs	NF-κB	[83]
	CD147	A2780, OVCAR3, SKOV3	HUVECs	CD147/MMP	[85]
	PKR1	A2780, HO8910	HUVECs	STAT3	[86]
	sE-cad	CAOV3, OV90	HUVECs	NF-κB	[87]
Targeted metastasis	CD44	HeyA8, TYK-nu	Peritoneal mesothelial cells	CD44/MMP9	[94]
	ACTN4, type IV collagen	SKOV3	N/A	Wnt/β-catenin	[95]
	L1CAM, CD24, ADAM10, EMMPRIN	SKOV3, malignant ascites (n = 3)	N/A	N/A	[25]
	MMP1 mRNA	ES-2, malignant ascites (n = 6)	Peritoneal mesothelial cells	Apoptosis	[43]
	CircRNA PUM1	A2780, CAOV3	Peritoneal mesothelial cells	NF-κB, MMP2	[97]
	CircRNA WHSC1	CAOV3, OVCAR3	Peritoneal mesothelial cells	Regulate MUC1 and hTERT	[98]

Abbreviations: ACTN4 actinin alpha 4, ADAM10 a disintegrin and metalloproteinase 10, CD cluster of differentiation, EMMPRIN extracellular matrix metalloproteinase inducer, hTERT human telomerase reverse transcriptase, HUVECs human umbilical vein endothelial cells, JAK janus kinase, L1CAM L1 cell adhesion molecule, MMP matrix metallopeptidase, MUC mucin, N/A not available, NF-κB nuclear factor kappa B, PKR1 prokineticin receptor 1, PUM1 pumilio RNA binding family member 1, sE-cad soluble E-cadherin, STAT3 signal transducer and activator of transcription 3, STAT3 signal transducer and activator of transcription 3, VEGFA vascular endothelial growth factor A, VEGFR2 vascular endothelial growth factor receptor 2, WHSC1 Wolf–Hirschhorn syndrome candidate 1.