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. 2022 Jan 18;13:302. doi: 10.1038/s41467-021-27656-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Genome representation of phage M1 and comparison, using a BLASTn analysis, with Slopekvirus type species KP15 (a). Each white or colored arrow represents a predicted open reading frame. In orange, genes encoding packaging and lysis-associated proteins are displayed, in yellow structural proteins and in blue DNA- and metabolism-associated proteins (adapted from EasyFig 2.2.2). The single missense mutation found in the preadapted phage M1 isolate used for therapy is indicated (gp269). AlphaFold2 model of the hinge connector of the distal tail fiber (b). The mutation of a Threonine to an Arginine is indicated (position 94). Alpha helices are indicated in red and beta sheets in yellow. Green stretches exhibit no specific structures. The model quality scores are presented to the right of the model. lDDT local distance difference test.