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. 2022 Jan 18;13:302. doi: 10.1038/s41467-021-27656-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Relevant clinical, biological, microbiological, and radiological parameters before (within 3 days before, or – for microbiological parameters – during surgery) and after treatment (a). CRP, C reactive protein; CT, computed tomography; ESR, erythrocyte sedimentation rate; PDR pandrug-resistant, WBC white blood cells. Antero-external view of the patient’s left hip and thigh 18 months before and 3 months after treatment (b). Successive computed-tomography scanners of the left femur before (admission, June 2017 and February 2018) and after treatment (June 2018 and June 2019) (c). Neutralization of pre-adapted phage M1 by antibodies produced by the patient’s adaptive immune system upon phage treatment. Bars represent the mean values of biological replicates (n = 6), each represented by a circle, with error bars representing standard deviations of the means (d). Source data are provided as a Source Data file.