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. 2022 Jan 18;13:373. doi: 10.1038/s41467-022-27989-3

Fig. 2. Substrate scope of the reaction.

Fig. 2

Reaction conditions: 1 (0.1 mmol), CuCl (10 mol%), L1 (15 mol%), (R)-CPA (0.1 mmol), toluene (2.0 mL), 20 °C for 36 h. The yield of isolated products. Ee values were determined by chiral HPLC. OPMB = p-methoxybenzylb. The single-crystal X-ray of 2h contains one molecule of H2Oc. There are conformers that existed around the red arrow.