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. 2022 Jan 18;12:936. doi: 10.1038/s41598-022-04976-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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LCRs in VOCs (Alpha, Beta, Gamma and Delta variants), VOIs (Epsilon, Eta, Iota, Kappa and Lambda variants) and Other SARS-CoV-2 proteomes (Others). (a) LCRs present in ORF1ab, which includes nsp1-4, 3CL protease (3CL), nsp6-nsp11, RdRp polymerase (RdRp), Helicase (Hel) and nsp 14-16. (b) LCRs along spike, ORF3a (3a), envelope (E), membrane (M), ORFs 6, 7a, 7b, 8, nucleocapsid (N) and ORF10. The Spike LCR sequences reported here in the Delta, Iota and Kappa variants are represented with red lines. The width of the lines is not proportional to the number of sequences in each variant.