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. 2022 Jan 18;12:936. doi: 10.1038/s41598-022-04976-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Complexity of the spike proteins of VOIs, VOCs and other SARS-CoV-2. The x axis shows the number of amino acid residues and the y axis shows the complexity level. A) The complexity level of each variant is in a different color: Iota—blue; Delta—dark red; Kappa—green. B) Complexity of the Delta spike proteins. The complexity level of the subsets is in a different color: Delta sensu lato—dark red; Variants AY—salmon pink; lineage B.617.2—bright red.