Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 18;12:936. doi: 10.1038/s41598-022-04976-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(a) The SARS-CoV-2 spike protein three-dimensional structure (by cryo-electron microscopy²⁴, PDB code: 7BNM). The structure corresponds to a trimer, where each monomer is represented with a different color. The two subunits that make up each monomer (Subunit 1, also known as Head region, and Subunit 2, or the Stalk region) are indicated. (b) Domain organization of the spike protein. The position of each of the LCRs found in this work, together with the mutations present in each variant spike protein are shown. The position of the signal peptide (SP) and Spike LCR-1 are indicated. The green arrow in the Spike LCR-3 box indicates the furin cleavage site. (c) Monomer of the spike protein. Close ups of each of the structural regions corresponding to the different LCRs are shown in colored boxes. The sequences of each LCR are represented, with the mutations indicated with a red letter. Protein structures in panels a and c were rendered using PyMOL (The PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC.). Panel b was created with BioRender.com. Abbreviations: SP, signal peptide; NTD, N-terminal domain; RBD, receptor-binding domain; RBM, receptor-binding motif; SD1, subdomain 1; SD2, subdomain 2; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 2; TM, transmembrane domain.