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. 2022 Jan 18;12:906. doi: 10.1038/s41598-021-04708-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The collagen density of dermis layer of subject’s back skin without and with UV-induced photoageing after topically applied with saline (Normal skin and UV-induced skin), CoQ10-loaded Emulgel, CoQ10 dissolved in oleic acid (CoQ10-Ole) Emulgel, and protransfesomal CoQ10 (Protransf-CoQ10) Emulgel once every 2 days for 2 weeks. *P < 0.05 compared to UV-induced skin, #P < 0.05 compared to Normal Skin.