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. 2022 Jan 18;13:372. doi: 10.1038/s41467-021-27583-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Matrix representations of pairwise comparisons between phages, show that: a occurrence of shared replicative hosts, does not reflect b occurrence of sharing of ≥1 25-mer between phages of different VIC-genera and morphotypes; in both panels phages are ordered based on manual sorting of VICTOR genus-level trees into groups by morphotype irrespective of their higher order clustering (where VIC-genera of different morphotypes can be intermingled, see Methods for details and Supplementary Data 8 for full original VICTOR phylogeny not sorted by morphotype); each of the 49 VIC-genera are represented as a distinct group indicated by a circle filled with the color representing the morphotype of the VIC-genus (purple: non-tailed; red: myovirus; yellow: podovirus; green: siphovirus). VICTOR trees represent Genome BLAST Distance Phylogenies (GBDP) based on concatenated protein sequences for each phage genome, with branch lengths representing intergenomic distances scaled in terms of the GBDP distance formula d₆. Extent of sequence sharing that can occur between phage morphotypes and genera that are largely non-overlapping in host killing is revealed by: c network visualization of phage genome connectivity by Mash distance, which is defined by sharing of 25-mers; and d occurrence of extensive sequence similarity between phages of different morphotypes, as visualized here using Blast Ring Image Generator (BRIG), for which specific directional horizontal gene transfer events can also be detected using MetaCHIP. Source data for panels a, b, c, and d are provided in Source Data Fig. 5, see Methods for strain sets included in the analyses; annotations for genes shown in panel d are provided in Supplementary Data 6, see Methods for information on methods for defining “structural”, “non-structural” (defined as “other” in Supplementary Data 6), or “no prediction”. Phage icon source: ViralZone www.expasy.org/viralzone, Swiss Institute of Bioinformatics.

Source Data Fig. 5.