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. 2022 Jan 5;12:788315. doi: 10.3389/fimmu.2021.788315

Table 2.

Enrichment of cell types in each condition and menstrual phase and their fluctuation throughout the menstrual cycle.

Population (Signif. Stages Strat.When not both) Disease vs Control Variation across the cycle
Enriched in Signif. Control Endo
Phase
Strat. PE ESE MSE PE ESE MSE
γδTcells Control (n = 34) PE +++ ++~ + ◊~ ++ ++ ++
CD4+ memory T cells PE +++ +++ +++ + +++ ++
Th2 cells PE, ESE +++ +++~ + ~ ++ ++ +
DC Endo (n = 71) All + + ++ +++ ++ +++
iDC (stages III-IV) PE +++ *◊ ++ * ++ +++ *◊ ++ * ++
aDC All + + ++ +++ ++ +++
pDC PE, MSE + + ++ ++ ++ ~ +++ ◊~
Monocytes PE, MSE + + + ++ + ~ ++ ◊~
Macrophages PE, MSE + + ~ ++ ◊~ ++ ++ ~ +++ ◊~
Macrophages M1 All + + ~ ++ ~ +++ ++ ~ +++ ~
Macrophages M2 All + + ~ ++ ◊~ +++ * ++ *~ +++ *~
NK cells (Stages III-IV) None + + ++ + ++ ~ +++ ◊~
Neutrophils PE + + + + + +
Eosinophils All + + ++ ++ * + * ++
Basophils PE, MSE + ++ +++ +++ ++ ~ +++ ~
CD8+ Tem All + + ~ ++ ◊~ ++ ++ ~ +++ ◊~
CD4+ naïve PE, ESE + + ~ +++ ◊~ ++ ++ ~ +++ ◊~
CD4+ Tcm PE, ESE + + ~ +++ ◊~ ++ ++ ~ +++ ~
CD4+ Tem All + + ~ ++ ◊~ +++ * ++ *~ +++ ~
Th1 (stages I-II) PE, MSE +++ ++ + +++ *◊ ++ * ++
Endothelial cells PE ++ ++ ++ +++ ++ +++
mv Endothelial All + + ~ ++ ~ +++ * ++* ~ +++ ~
ly Endothelial All ++ * + * + +++ * ++ * +++
Epithelial cells PE, MSE + ++ +++ + ++ ~ +++ ◊~
Keratinocytes All + ++ +++ +++ ++ +++
Skeletal muscle cells PE, MSE + + + ++ ++ ++
Neurons (phase strats only) PE, MSE +++ ◊* ++ * + ++ *◊ + * +
Astrocytes (phase strats only) MSE +++ ++ + +++ *◊ ++ * ++
Erythrocytes (phase strats) MSE +++ ++ ~ + ◊~ ++ ++ +
MPP All + + ~ ++ ◊~ ++ + ~ ++ ~
HSC PE, ESE + *◊ ++ * +++ +++ +++ +++

Significant differences between: * = PE and ESE; ~ = ESE and MSE; ◊ = PE and MSE.

Abundance of the cell type = +/++/+++.

Unstrat., Unstratified.