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. 2021 Mar 5;12(1):135–143. doi: 10.1016/j.jceh.2021.03.001

Table 2.

Comparison of Characteristics among Modified Llop Severity Grades.

Severity grade (Llop)
Feature		 Grade 1
(n = 4)		 Grade 2
(n = 18)		 Grade 3
(n = 31)		 P value
Age in years (Median, IQR) 11.9 (8.3,14.6) 10.9 (8.3,13) 10.2 (7.7,12.8) 0.74
Gender (Boys, n [%]) 4 (100) 13 (72) 20 (65) 0.33
Duration of disease in years (Median, IQR) 2.5 (0.3, 7.5) 3.2 (0.3, 5.7) 2.3 (0.5, 5.8) 0.98
Lab parameters (Median, IQR)
  • 1.

    Total bilirubin (mg/dl)

 1.05 (0.3, 1.4) 0.8 (0.6,1.1) 0.8 (0.5,1) 0.63
  • 2.

    Conjugated bilirubin (mg/dl)

 0.25 (0.1,0.3) 0.2 (0.1,0.2) 0.2 (0.1,0.4) 0.28
  • 3.

    AST (U/L)

 30.5 (23.2,40) 38.5 (26.5,42) 34 (27,44) 0.57
  • 4.

    ALT (U/L)

 20 (18,27) 27.5 (19,35) 28 (20,38) 0.41
  • 5.

    ALP (U/L)

 174 (92,264) 211 (154,261) 199 (139,280) 0.63
  • 6.

    GGT (U/L)

 10.5 (7.7,11.7) 11.5 (10.7,16) 12 (10,18) 0.24
  • 7.

    Serum total protein (g/dl)

 6.5 (4.8,6.9) 7.2 (7,7.6) 7.2 (6.9,7.6) 0.04
  • 8.

    Serum albumin (g/dl)

 3.7 (2.9,4.1) 4.2 (4,4.6) 4.2 (3.9,4.3) 0.07
  • 9.

    Hemoglobin (g/dl)

 9.6 (8.3,11.6) 11 (9.6,12) 10 (8.9,11.7) 0.27
  • 10.

    Total leucocyte count (x109/L)

 4.7 (3.8,6.5) 5.4 (4.3,6.8) 4.3 (2.6,6.1) 0.08
  • 11.

    Platelet count (x109/L)

 86 (60,97) 107 (77,151) 78 (54,102) 0.06
  • 12.

    INR

 1.1 (1, 1.2) 1.1 (1, 1.2) 1.1 (1, 1.2) 0.98
Type of block n (%) 0.84
  • 1.

    PV alone

 3 (75%) 8 (44.5%) 13 (42%)
  • 2.

    PV along with SV±SMV

 1 (25%) 10 (55.5%) 18 (58%)
CBD angle (Mean ± SD) 157.7 ± 10.6° 141.4 ± 5.9° 136.1 ± 12° <0.01
EUS changes n (%)
  • 1.

    Para-pericholedochal collaterals

 2 (50%) 17 (94.4%) 30 (96.7%) <0.01
  • 2.

    Intracholedochal collaterals

 0 (0) 2 (11.1%) 3 (9.7%) 0.78
  • 3.

    GB wall thickening

 1 (25%) 8 (44.4%) 25 (80.6%) <0.01
  • 4.

    Intramural GB collaterals

 1 (25%) 12 (66.7%) 26 (84%) <0.01
  • 5.

    Intrapancreatic collaterals

 1 (25%) 13 (72.2%) 26 (84%) <0.01
  • 6.

    GB calculus/sludge

 0 (0) 2 (11.1%) 3 (9.7%) 0.78

AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, gamma glutamyl transferase; INR, international normalised ratio; PV, portal vein; SV, splenic vein; SMV, superior mesenteric vein; EUS, endoscopic ultrasound; CBD, common bile duct; GB, gall bladder.