Table 1.
Baseline characteristics of included participants by level of estimated glomerular filtration rate (eGFR, ml/min/1.73 m2) in the CRIC study
| eGFR < 30 | eGFR 30–44 | eGFR 45–59 | eGFR ≥ 60 | |
|---|---|---|---|---|
| N | 378 | 766 | 732 | 436 |
| Age (years) | 56.3 (12.1) | 57.3 (11.8) | 56.3 (10.8) | 49.8 (10.9) |
| Male | 189 (50) | 387 (51) | 412 (56) | 231 (53) |
| Race/ethnicity | ||||
| White | 115 (30) | 301 (39) | 339 (46) | 226 (52) |
| Black | 157 (42) | 299 (39) | 282 (39) | 155 (36) |
| Hispanic | 91 (24) | 135 (18) | 76 (10) | 35 (8) |
| Other | 15 (4) | 31 (4) | 35 (5) | 20 (5) |
| Highest level of education | ||||
| Less than HS | 117 (31) | 191 (25) | 101 (14) | 36 (8) |
| HS | 86 (23) | 133 (17) | 126 (17) | 65 (15) |
| Some college | 95 (25) | 223 (29) | 209 (29) | 136 (31) |
| College or above | 80 (21) | 219 (29) | 296 (40) | 198 (45) |
| Current smoking | 52 (14) | 101 (13) | 70 (10) | 54 (12) |
| Height (cm) | 166.4 (9.7) | 167.7 (9.8) | 169.3 (9.6) | 170.5 (9.6) |
| Weight (kg) | 88.5 (23.6) | 90.1 (22.2) | 90.7 (24.1) | 90.2 (22.2) |
| BMI (kg/m2) | 32.0 (8.2) | 32.0 (7.7) | 31.6 (8.1) | 31.0 (7.1) |
| Diabetes at baseline | 187 (49) | 371 (48) | 286 (39) | 124 (28) |
| Hypertension | 349 (92) | 688 (90) | 614 (84) | 272 (62) |
| Antihypertensive medications | 357 (94) | 715 (93) | 632 (86) | 294 (67) |
| Statins | 202 (53) | 367 (48) | 338 (46) | 137 (31) |
| Systolic blood pressure (mmHg) | 132.6 (23.5) | 129.2 (21.4) | 125.9 (19.9) | 120.4 (18.1) |
| LDL (mg/dL) | 104.7 (37.6) | 104.0 (35.9) | 108.1 (34.4) | 110.7 (32.5) |
| HDL (mg/dL) | 46.8 (14.7) | 48.0 (15.8) | 49.8 (16.9) | 50.0 (16.9) |
| eGFR (mL/min/1.73m2) | 24.7 (3.9) | 38.1 (4.3) | 52.0 (4.4) | 69.5 (8.8) |
| 24-hour urine protein (g), median (IQR) | 0.7 (0.2–2.2) | 0.3 (0.1–1.2) | 0.1 (0.1–0.4) | 0.1 (0.1–0.2) |
| Left ventricular hypertrophy by Year 1 echocardiogram** | 147 (39) | 221 (29) | 194 (27) | 82 (19) |
| LVEF < 50% by Year 1 echocardiogram | 34 (9) | 83 (11) | 84 (11) | 58 (13) |
| NT-proBNP (pg/mL), median (IQR) | 255.6 (109.6–513.1) | 111.9 (54.7–250.8) | 64.9 (25.8–160.2) | 35.4 (9.2–91.0) |
| Undetectable (<5 pg/mL) NT-proBNP* | 7 (2) | 24 (3) | 74 (10) | 78 (18) |
| hsTNT (ng/L), median (IQR) | 21.4 (11.8–41.0) | 14.3 (8.8–23.6) | 11.0 (7.3–17.0) | 7.6 (5.3–11.5) |
| Undetectable (< 3 ng/L) hsTNT* | 1 (0) | 5 (1) | 12 (2) | 20 (5) |
Entries are mean (SD) for continuous variables or N (%) for categorical variables, except as noted.
*
Undetectable limits are 5 pg/mL for NT-proBNP and 3 ng/L for hsTNT;
**
Defined as LVM (Cornell) ≥ 50 for males, LVM (Cornell) ≥ 47 for females