TABLE 3.

Univariable logistic regression for ICU- and 28-day mortality in the sepsis cohort. Abbreviations: HDL, high density lipoprotein; ICU, intensive care unit; SOFA, sequential organ failure assessment; LCAT, lecithin-cholesterol acyltransferase; CETP, cholesteryl ester transfer protein; PLTP, phospholipid transfer protein.

Outcome variable	28-day mortality			ICU mortality
Variable	Odds ratio	95% confidence intervall	p	Odds ratio	95% confidence intervall	p
Demographics
Age (per 5 years increase)	1.23	1.02–1.50	0.033	1.06	0.89–1.27	0.511
Female sex	2.71	0.87–8.43	0.085	1.65	0.53–5.17	0.390
Quantitative lipid parameters
HDL cholesterol (per 10 mg/dl increase)	0.88	0.66–1.18	0.381	0.84	0.61–1.17	0.312
Triglycerides (per 10 mg/dl increase)	0.98	0.93–1.04	0.501	0.99	0.93–1.05	0.715
Total cholesterol (per 10 mg/dl increase)	0.90	0.79–1.02	0.088	0.89	0.78–1.02	0.099
Laboratory covariables
White blood count (per 1G/L increase)	1.02	0.98–1.07	0.357	1.00	0.96–1.05	0.960
C-reactive protein (per 100 mg/L increase)	1.72	1.07–2.77	0.025	1.40	0.90–2.18	0.136
Procalcitonin (per 1 ng/ml increase)	1.00	0.99–1.01	0.339	1.00	0.99–1.01	0.170
Interleukin-6 (per 100 pg/mL increase)	1.02	0.99–1.06	0.267	1.03	0.99–1.06	0.160
Lipid metabolism markers
Endothelial lipase (per 100 pg/ml increase)	1.10	0.92–1.32	0.310	1.11	0.92–1.33	0.270
Serum amyloid A (per 1,000 μg/ml increase)	0.93	0.77–1.12	0.425	0.86	0.70–1.06	0.157
LCAT activity (per 1% increase in substrate turnover per hour)	0.39	0.19–0.77	0.006	0.51	0.28–0.91	0.023
LCAT concentration (per 1 μg/ml increase)	0.06	0.90–1.03	0.285	0.95	0.89–1.03	0.210
CETP (per 1 pmol/h increase)	0.94	0.78–1.14	0.542	0.98	0.80–1.19	0.811
PLTP (per 1 pmol/h increase)	1.04	0.88–1.23	0.641	1.10	0.92–1.31	0.306
Sepsis severity and outcomes
SOFA score (per 1 point increase)	1.13	0.97–1.31	0.113	1.36	1.12–1.65	0.002