TABLE 4.
Multivariable logistic regression for 28-day (A) and ICU- (B) mortality in the sepsis cohort.
| Outcome variable | |||
|---|---|---|---|
| Variable | Odds ratio | 95% confidence intervall | p |
| A | 28-day mortality | ||
| Model #1 | |||
| LCAT (per 1% increase in substrate turnover per hour) | 0.44 | 0.20–0.93 | 0.031 |
| Age (per 5 years increase) | 1.20 | 0.98–1.47 | 0.077 |
| CRP (per 100 mg/dl increase) | 1.22 | 0.70–2.21 | 0.493 |
| Model #2 | |||
| LCAT (per 1% increase in substrate turnover per hour) | 0.49 | 0.22–1.08 | 0.076 |
| SOFA score (per 1 point increase) | 1.13 | 0.93–1.36 | 0.212 |
| Age (per 5 years increase) | 1.25 | 0.99–1.58 | 0.051 |
| CRP (per 100 mg/dl increase) | 1.24 | 0.70–2.21 | 0.454 |
| B | ICU mortality | ||
|---|---|---|---|
| Model #1 | |||
| LCAT (per 1% increase in substrate turnover per hour) | 0.59 | 0.31–1.13 | 0.111 |
| SOFA score (per 1 point increase) | 1.31 | 1.07–1.59 | 0.008 |
Variables with a p ≤ 0.05 in univariable logistic regression were considered in the multivariable models. An additional exploratory model with variables significant in univariable logistic regression and also including the SOFA, score was performed for 28-day mortality (model #2). Abbreviations: ICU, intensive care unit; SOFA, sequential organ failure assessment; LCAT, lecithin-cholesterol acyltransferase.