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. 2022 Jan 5;12:780804. doi: 10.3389/fimmu.2021.780804

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Copyright © 2022 Zhang, Li, Wang, Sun, Wei, Zhang, Wu and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage-derived IL18 regulates HIF-1 signaling through IL18R1. A.UMAP scatter plot of cell types in the heart of COVID-19 patients derived from GSE171668. (A) total of 29,472 cells were included in 9 types. (B) The molecular regulatory network between macrophages and cardiomyocytes. (C) The molecular regulatory network between macrophages and vascular smooth muscle cells. (D) The molecular regulatory network between macrophages and endothelial cells. There are four layers of ligand, receptor, TF and Target genes in the networks, which were marked by different colors. Up-regulated genes in aneurysm and atherosclerosis were marked in (B–D). (E) Expression distribution of IL18, IL18R1 and HIF-1A in different cell types.