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. 2022 Jan 5;12:780804. doi: 10.3389/fimmu.2021.780804

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Copyright © 2022 Zhang, Li, Wang, Sun, Wei, Zhang, Wu and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL18 is involved in the progression of COVID-19, and the methylation pattern of PBMC changes after infection. (A) Expression of IL18 in patients with different clinical severity of COVID-19(mild:5 patients; moderate:6 patients; serious: 4 patients; p=0.367; Games-Howell test) (B) Expression of IL18 in patients with different stage of COVID-19(convalescence:14 patients; rehabilitation:9 patients; treatment: 15 patients; p=0.079; Games-Howell test) (C) Heat map of PBMC methylation differential sites after SARS-CoV-2 infection (D) Enrichment analysis of differential methylation sites after SARS-CoV-2 infection. (Pvalue<0.05).