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Current approaches of KRAS-mutant NSCLC. NSCLC, non-small cell lung cancer; KRAS, kirsten rat sarcoma viral oncogene homolog; PD-1, programmed cell death protein 1; PD-L1, programmed cell death-ligand 1; CTLA4, cytotoxic T-lymphocyte-associated protein 4; Raf, rat fibrosarcoma; MEK, mitogen-activated protein kinase kinase; PI3K, phosphoinositide 3-kinase; Akt/PKB, protein kinase B.
