Figure 5.

Alignment of selected PEPs with the viral spike sequences. The peptides were derived from a part of the SARS-CoV-2 spike S2 domain (residues 806-1091), encompassing the S2′ cleavage site, fusion peptide and heptad repeat 1. On the left, the structure of the SARS-CoV-2 spike in closed conformation is shown (PDB 6ZGE). The right panel shows an alignment of the relevant S2 sequences of SARS-CoV-2 (NCBI accession number YP_009724390), HCoV-OC43 (YP_009555241) and HCoV-229E (NP_073551), as well as the corresponding peptides. Sequence similarities from Clustal Omega-aligned sequences were rendered using ESPript 3.0. Shown in red shading: fully conserved residues; in red font: residues are similar according to physicochemical properties; and boxed in blue: ≥70% similarity. Secondary structure depiction shown on top was derived from PDB 6ZGE.