Table 7.

Drugs related to TGF-β and TNF-α.

Drugs	Mechanism
TGF related drugs
LY3022859 ( 124 )	Inhibition of TGF-β receptor-mediated activation of transforming growth factor-β signaling.
Fresolimumab ( 125 )	Interfering With Ligand-Receptor Interactions.
264RAD ( 126 )	Blocks integrin-mediated TGF-β activation to target the TGF-β signaling pathway.
TNF-related drugs
Infliximab, Adalimumab, Golimumab	Inhibits binding of TNF to its receptors to neutralize activation of TNFR1 and TNFR2.
Etanercept	Prevents TNF binding to TNFR2.
Certolizumab pegol	Selectively neutralize TNF-α.