Figure 3.

Identification of DEGs and Screening of Hub Genes. (A) Volcano plot for DEGs between healthy controls and ANCA-GN tissues. (B) Venn diagram for intersections between DEGs and the black module. (C) Partial likelihood deviance with changing of log (λ) plotted by LASSO regression in 10-fold cross-validations. Dotted vertical lines were drawn at the optimal values using the minimum criteria (lambda.min) and 1 standard error of the minimum criteria (1-SE criteria). (D) The LASSO coefficient profiles for five hub genes in the 10-fold cross-validation. DEGs, differentially expressed genes; ANCA-GN, Antineutrophil cytoplasmic antibody-associated glomerulonephritis; LASSO, least absolute shrinkage and selection operator.