Fig. 5.

Silencing of SDC2 in hMSCs results in increased tissue expression of proinflammatory mediators. RNA was also harvested from spleen, liver, and lung tissue, and qRT‐PCR was performed for IL‐6 (A) and MCP‐1 (B). Mice undergoing CLP were randomly assigned to receive PBS control (gray bars, n = 20 in each group), shSCR hMSCs (blue bars, n = 20 in each group), or shSDC2 hMSCs (red bars, n = 16 for IL‐6, n = 18 for MCP‐1). Data are presented as mRNA levels of IL‐6 or MCP‐1 normalized for β‐actin, as a fold change to sham (white bars), mean ± SEM. P < 0.0001 with significant comparisons * versus sham, † versus PBS, ‡ versus shSCR hMSCs.