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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Immunol Rev. 2021 Nov 8;305(1):43–58. doi: 10.1111/imr.13034

Figure 1.

Figure 1.

Schematic representation of the Aire protein and its functions. (A) Model of domains identified in human Aire. Known dominant-negative mutations are also indicated. (B) The diagram lists posttranslational modifiers of Aire, Aire interacting proteins, and molecular processes leading to Aire-mediated tissue-restricted antigen expression in mTEChi.