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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: J Hepatol. 2021 Sep 30;76(2):383–393. doi: 10.1016/j.jhep.2021.09.021

Figure 5. Hormonal dependence of T39’s effect on hepatic lipogenic genes in females.

Figure 5.

(A) Hepatic T39 and (B) Rb1 expression in male and female mice fed HFSC diet in the refed state, n=26–34 per group, ****p<0.001 by Mann-Whitney test. (C) Hepatic pRb protein expression in male and female mie fed the HFSC diet for 10 weeks, n=9–11 per group, *p<0.05 by Mann Whitney U-test. (D) Hepatic Pnpla3 expression in male and female mice fed HFSC diet in the fasting and refed state, n=5–9 per group, **p<0.01, ***p<0.001, ****p<0.001 by two-way ANOVA with Sidak’s multiple comparisons test. (E) Hepatic pRb protein level, (F) hepatic gene expression and (G) hepatic triglyceride content of refed ovariectomized or sham-operated female mice fed HFSC diet for 10 weeks, n=10 per group, *p<0.05, **p<0.01 and ***p<0.001 by two-way ANOVA with Sidak’s multiple comparison’s test where the column factor is T39 ASO.