Table 1.

Whole brain weights in Lal ^+/+ and Lal ^−/− mice from before weaning until late-stage disease

Age (days)	Genotype	No. of mice ♂ / ♀	Body weight (g)	Whole brain weight (g)
14	Lal +/+	3 / 0	7.2 ± 0.4	0.381 ± 0.005
	Lal −/−	2 / 3	7.0 ± 0.4	0.379 ± 0.006
21	Lal +/+	3 / 2	11.3 ± 0.6	0.418 ± 0.005
	Lal −/−	4 / 2	10.3 ± 0.6	0.402 ± 0.007
35	Lal +/+	2 / 4	18.6 ± 0.9	0.425 ± 0.008
	Lal −/−	1 / 5	19.0 ± 0.2	0.423 ± 0.006
50	Lal +/+	2 / 2	23.9 ± 1.2	0.457 ± 0.004
	Lal −/−	1 / 3	23.1 ± 1.5	0.429 ± 0.001*
68-76	Lal +/+	8 / 5	27.3 ± 1.2	0.473 ± 0.003
	Lal −/−	7 / 7	25.5 ± 0.8	0.440 ± 0.005*
140-142	Lal +/+	0 / 5	26.4 ± 0.5	0.485 ± 0.008
	Lal −/−	0 / 5	23.8 ± 1.0*	0.400 ± 0.003*
230-280	Lal +/+	3 / 2	34.1 ± 2.2	0.499 ± 0.008
	Lal −/−	3 / 3	27.9 ± 1.3*	0.398 ± 0.008*

After weaning at ~21 days, all mice were fed ad libitum a cereal-based, low-fat rodent diet. All mice were of the FVB/N strain.

Values are mean ± SEM for the number of mice indicated.

^*p < 0.05 compared to the corresponding value for matching Lal ^+/+ mice.