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. 2021 Aug 17;48(1):e12753. doi: 10.1111/nan.12753

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© 2021 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Protein–protein interaction (PPI) network analysis reveals complex functional changes in Alzheimer's disease reactive astrocytes (ADRA). (A) STRING PPI functional network analysis on the 196 ADRA proteins resulting from our systematic review demonstrates a highly connected network with IL6, TNF and MAPK 1, 3, and 8 as top hub proteins. (B) Chord diagram based on expert annotation of the 196 ADRA markers in one of 18 functional categories shows the high interconnectivity of the functional alterations of ADRA