Table 1.
Baseline, Pre-Systemic Therapy Characteristics of Older Women with Breast Cancer Treated with Chemotherapy by Taxane Regimen in a Pooled Cohort Sample
| Chemotherapy with taxanes (N=116) | Chemotherapy without taxanes (N=51) | p-value | |
|---|---|---|---|
| Mean (SD) or n (%) | |||
| Demographics | |||
| Age, years | 67.0 years (4.8) | 68.0 years (4.6) | 0.23 |
| More than high school education | 68 (58.6%) | 30 (58.0%) | 0.94 |
| Clinical | |||
| Stage at diagnosis | 0.07 | ||
| Stage 1 | 39 (33.3%) | 26 (51.0%) | |
| Stage 2 | 51 (43.9%) | 19 (37.3%) | |
| Stage 3 | 26 (22.8%) | 6 (11.8%) | |
| Chemotherapy Regimens | |||
| Taxane alone | 38 (32.8%) | 0 (0%) | |
| Taxane + anthracycline | 78 (67.2%) | 0 (0%) | |
| Anthracycline-based alone* | 0 (0%) | 34 (65.7%) | |
| Non-anthracycline-based alone* | 0 (0%) | 17 (34.3%) | |
| Hormonal therapy regimens | 0.43 | ||
| Aromatase inhibitor | 75 (64.7%) | 24 (47.1%) | |
| Tamoxifen | 2 (1.7%) | 0 (0%) | |
| No hormonal therapy | 39 (33.6%) | 27 (52.9%) | |
| Instrumental ADL score* | 0.50 (0.95) | 0.37 (0.92) | 0.41 |
| Cognition | |||
| FACT-Cog Total | 112.7 (15.44) | 115.9 (16.36) | 0.28 |
| FACT-Cog Perceived Cognitive Impairment | 61.44 (10.14) | 63.13 (10.51) | 0.37 |
| Trail Making A z-score** | 0.11 (1.15) | −0.35 (1.85) | 0.05 |
| Trail Making B z-score** | −0.30 (2.55) | −0.82 (2.80) | 0.24 |
| Digits Span z-score | −0.18 (0.89) | −0.03 (0.95) | 0.35 |
| Quality of Life/Function | |||
| FACT-G Physical Well-Being | 21.09 (4.86) | 22.30 (3.28) | 0.15 |
| FACT-G Social Well-Being | 18.84 (3.33) | 18.05 (2.84) | 0.19 |
| FACT-G Emotional Well-Being | 14.14 (4.46) | 14.75 (4.75) | 0.47 |
Note: Ranges for FACT self-report measures: FACT-Cog total (range 0–132), FACT-Cog PCI range (0–72), FACT Physical Well-Being (range 0–24), FACT Social Well-Being (range 0–20), FACT Emotional Well-Being (range 0–16)
*
total number with any impairment
**
reversed scores: higher=better