Table 2.
Factors Associated with Longitudinal Scores for Objective Cognitive Performance1
| Trail making A | Trail making B | Digit Span | |
|---|---|---|---|
| Covariates | β (95% CI) | β (95% CI) | β (95% CI) |
| Age, per 1 year increase | .00 (−.04 – .03) | .00 (−.08 – .07) | .01 (−.01 – .03) |
| CogAge vs. TLC | .64 (.18 – 1.18)** | 1.29 (.39 – 2.19)** | −.31 (−.60 - −.01)* |
| High School vs <=HS Education | .32 (−.10 – .75) | .30 (−.52 – 1.12) | .74 (.48 – 1.01)*** |
| IADL, per increase in limitations | −.15 (−.32 – .02) | −.42 (−.75 – −.09)* | −.15 (−.25 – −.04)** |
| Hormone Therapy (Yes versus No) | .04 (−.30 – .39) | .08 (−.60 – .75) | −.05 (−.26 – .17) |
| Impact of Taxanes | |||
| Taxane vs. non taxane regimen | −.21 (−.63 – .23) | .34 (−.49 – 1.16) | .04 (−.23 – .32) |
| Time effect, pre-treatment to 12-months | .04 (−.16 – .25) | .05 (−.34 – .44) | .04 (−.09 – .17) |
| Taxane group × pre-treatment to 12-month | .31 (−.08 – .70) | .78 (.04 – 1.52)* | −.05 (−.30 – .21) |
| Time effect, 12- to 36-months | .06 (−.08 – .20) | .03 (−.25 – .30) | .16 (.06 – .25)** |
| Taxane group × 12- to 36-months | −.01 (−.29 – .27) | −.51 (−1.04 – .02) | −.11 (−.29 – .07) |
*
p < .05,
**
p < .01,
***
p < .001
1
Results for piecewise multilevel models modeling change in objective cognitive performance. Sample reference group is TLC; Education reference group is high school completion; treatment group reference is chemotherapy with taxane.