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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2021 Sep 3;162:97–109. doi: 10.1016/j.yjmcc.2021.08.011

Figure 3: Heterogeneity of beating rates among graft PSC-CMs can give rise to inconsistent graft-induced spontaneous ectopic beats in a host CM.

Figure 3:

(A) Heat maps show how the cycle lengths of graft-induced ectopic beats in a host ventricular CM (left) and spontaneously beating graft PSC-CMs (right) change with gap junctional resistance (Rgap) and cleft width for 1:4 host-graft coupling configuration; PSC-CMs had a range of Id (3.1, 3.3, 3.5, and 3.7 μA/μF) with initial states randomized. (B-E) Representative Vm traces of host and graft CMs (left) and junctional gating (right). A wide range of activation patterns were observed from (B) 1:1 capture and instances of (C) 3:1, (D) 5:1, and (E) 11:1 block. Across all traces, junction 4 exhibited the largest gating fluctuations.