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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Aliment Pharmacol Ther. 2021 Dec 21;55(3):277–291. doi: 10.1111/apt.16741

Table 2.

Characterization and preclinical investigations of S1PR modulators

Name Synonym Formula Affinity to S1PRs Animal colitis models investigated REF
Ozanimod RPC-1063 C23H24N4O3 S1PR1 and 5 TNBS-induced colitis in Sprague Dawley rats, Colitis in SCID mice by adoptive transfer of CD4+CD45RBhigh T cells 65,68
Etrasimod APD-334 C26H26F3NO3 S1PR1, 4 and 5 Colitis in SCID mice by adoptive transfer of CD4+CD45RBhigh T cells 80,81
Amiselimod MT-1303 C19H30F3NO3 S1PR1, 4 and 5 Colitis in SCID mice by adoptive transfer of CD4+CD45RBhigh T cells 83–86,92
KRP-203 KRP 203 C24H26ClNO3S S1PR1 Colitis in IL-10−/− mice 96–100
Fingolimod FTY720 C19H34ClNO2 S1PR1,3,4 and 5 Colitis in IL-10−/− mice, oxazolone-induced colitis, TNBS-induced colitis, DSS-induced colitis 102,104–106,122–124
Siponimod BAF312 C29H35F3N2O3 S1PR1 and 5 None 107,108
Ponesimod ACT-128800 C23H25ClN2O4S S1PR1 None 116
Cenerimod ACT-334441 C25H31N3O5 Mainly S1PR1 and 5 None 115,125