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Receptor binding and signaling analysis
| ActRIIA |
ALK3 |
Signaling | |||||
|---|---|---|---|---|---|---|---|
| ka (105) | kd (10−3) | KD (10−9) | ka (105) | kd (10−5) | KD (10−11) | EC50 (10−10) | |
| B4/4-GF | 3.3 | 1.2 | 3.5 | 5.1 | 1.4 | 2.8 | 8.7 |
| BMP-4 | 1.2 | 23.0 | 1.9 | 5.1 | 2.5 | 4.9 | 3.0 |
| BMP-4Δ | 8.3 | 6.3 | 7.2 | 5.9 | 1.3 | 2.2 | 0.5 |
| BMP-2 | 8.0 | 9.8 | 0.1 | 6.4 | 0.4 | 0.7 | 3.0 |
