Figure 2.

The effect of imipramine on alveolar bone loss induced by LPS and/or metabolic syndrome (MetS). C57BL/6 mice were fed HFD for 20 weeks to induce MetS and/or treated with LPS for the last 4 weeks to induce periodontitis (PD). Control mice were fed LFD or injected with PBS. Half of mice were also treated with imipramine in the last 7 weeks as described in Methods. After the feeding and treatments, the maxillae were scanned with μCT. Representative μCT image (A) and bone volume fractions (B) for 8 groups are shown (B). In addition, the liner distances between CEJ to ABC for the first and second molars are shown (C). The CEJ and ABC as well as the distance between CEJ and ABC of the first and second molars were presented (Fig. 2D). The data are mean ± SD (n=7–10). CEJ, cement–enamel junction; ABC, alveolar bone crest.